
Osteoporosis –
what can
you do about it?
From being thought of
as a disease affecting a few little old ladies with hunched backs,
osteoporosis
has leapt into the public consciousness – and with it, the
importance of
nutrition in maintaining bone health. Yet there remains confusion in
the
minds of many health-conscious people about the right dose and form of
even the most well-known bone health nutrients, while the importance of
other key nutrients in keeping the skeleton strong remains largely
unknown.
Bone loss accelerates suddenly in menopausal women because the drop in
estrogen levels causes an increase in the resorption (teardown) of
existing
bone. But resorption is only half of the story. Age-related bone loss
is
also caused by a decrease in the formation of new bone tissue.
Existing
drugs for treating osteoporosis, as well as calcium and vitamin D
supplements,
work by reducing bone resorption. But they do not support the formation
of new bone. These drugs and nutrients increase the mineralization of
bone,
but they do not help the body to build new bone tissue. And in
fact,
within weeks of starting use of antiresorptive drugs like Fosamax,®
the body’s formation of new bone actually decreases. The
resulting bone
is less prone to fracture, but is not the same as youthful, healthy
bone.
Often, since bone loss occurs in women after menopause, when hormones
decline,
it is suggested that they take estrogen. However, even though estrogen
does inhibit bone loss, it actually does nothing to build
new
bone. The hormone that is responsible for bone building is
progesterone.
Click here to learn more about the bone building activity of progesterone
We have been having excellent results with a mineral that also promotes
osteo-blasts (the putting in of new bone). Please read on.......
Strontiumis
a mineral found along with calcium in most foods. Research has long
suggested
that it may be an essential nutrient required for the normal
development,
structure, function, and health of the skeletal system. Clinical
trials going back into the 1940s have supported this conclusion, but
recent
studies have provided evidence that it can offer unique nutritional
support
against loss of bone structure and function. Animal studies have shown
that Strontium supplements both decrease bone resorption, and increase
the formation of new bone tissue.
•In animal models, Strontium (in various forms, such as chloride,
carbonate,
gluconate, and lactate) causes “baby” osteoblasts
(bone-building
cells) to multiply more quickly.
•Bone tissue cultures which are exposed to Strontium synthesize
more bone
matrix and new bone collagen. The same amount of calcium has no effect
on these parameters.
•In bone tissue culture, Strontium reduces bone resorption at
concentrations
at which calcium has no effect, prevents the resorption caused by
excessive
parathyroid hormone, and slows the rate at which immature osteoclasts
develop.
Human clinical trials also support Strontium’s ability to both
support
new bone formation and prevent excessive resorption.
•Bone biopsies from a small human pilot trial revealed an
astounding 172.4%
increase in new bone formation after six months of Strontium (gluconate)
supplementation.
•The bone-building activity of osteoblasts can be measured using
bone-specific
alkaline phosphatase, while crosslinked N-telopeptide (NTx) and
C-telopeptide (CTx) mark
the degradation of bone collagen by ravaging osteoclasts. Unlike the
range
of side-effects that accompany antiresorptive drugs, no clinical
side-effects
have ever been reported that could be clearly attributed to Strontium.
Calcium
and Strontium can both play key roles in the health of your bones
–
if you use them properly. On the one hand, animal studies suggest that
Strontium is not effective, and may even be counterproductive, if your
calcium intake is not adequate. At the same time,
however,
it’s important not to take your Strontium supplement at the same
time as
your calcium supplements. This is because calcium and Strontium use the
same pathways for absorption in the intestinal tract, so that
swallowing
a calcium supplement along with your Strontium can dramatically reduce
absorption.
The best protocol – and the one used in the most recent clinical
trials
– is to take your Strontium either three hours after your last
meal of
the day, or one hour before breakfast in the morning, or both. Because
studies suggest that one last dose of calcium just before retiring can
help prevent excessive resorption of bone overnight, it may be best to
take all of your Strontium before breakfast and mid-afternoon (2 hrs
away
from a meal), leaving you free to take a calcium supplement just before
you go to bed.
What is the best form of Calcium?
Ortho•Bone
- Related Research
A superior nutritional
supplement
for bone health must be built on a foundation of ossein
Microcrystalline
Hydroxyapatite Complex (MCHC) as the calcium source, and
fortified
with well-established nutrient cofactors such as Magnesium, Zinc,
Manganese,
Copper, Vitamin C, and Vitamin D3, as well as critical factors like
Menatetrenone (the
mammalian
form of vitamin K2) and Strontium, whose revolutionary effects on bone
health have only emerged recently. Here’s a quick review of the
controversies
and recent discoveries.
• Get Enough Calcium.
Current
“official” recommendations suggest an intake of 1000
milligrams of calcium
for younger adults, and 1200 milligrams for people over the age of 50.
Some evidence suggests that a still higher intake (1300-1600
milligrams)
of calcium is more effective for lowering fracture risk in the elderly.
But remember that these numbers are your total calcium need. The more
calcium
you get in your diet, the less you need from supplements.
• Get the Right Kind
of
Calcium. Too many health-conscious people believe that conventional
calcium
supplements (or conventional calcium plus vitamin D) can put an end to
bone loss. They can’t. As multiple studies have documented,
conventional
calcium supplements – such as calcium gluconate, calcium citrate,
and calcium
carbonate – slow, but do not halt or reverse, menopausal bone
loss, whether
taken alone or with vitamin D. You simply can’t force the bones
to take
in more calcium, and build more bone, by taking more and more calcium:
the mineral itself can only provide the raw material needed to support
your existing bone mass, or to allow other factors in your skeletal
health
program to build up new bone.
But there is one seeming
exception. Ossein microcrystalline hydroxyapatite complex (MCHC)
consistently
halts, or even reverses, bone loss in controlled human trials. When put
head-to-head against other calcium supplemental forms, MCHC
consistently
trumps conventional calcium supplements. But MCHC’s bone-building
powers
do not lie in the calcium itself.
True MCHC is not just a
form of calcium, but is a calcium-based crystalline nutrient complex,
which
is how the mineral is actually stored in your bones. MCHC’s
unique support
for the skeletal system is probably due to a combination of its intact
crystalline structure, and the vibrant blend of peptides,
mucopolysaccharides,
and growth factors which accompany the calcium in true MCHC supplements
– factors which are not present in conventional calcium
supplements, in
bone meal, or in pure, synthetic hydroxyapatite (also known as calcium
orthophosphate). The bottom line is that the unique bone health support
provided by MCHC derives from the whole supplement, and not just from
its
calcium content.
Calcium
Citrate-Malate
for Vegetarians and those who want the most economical, but effective
calcium.
Unfortunately, of course,
vegetarians cannot consume MCHC because it is an animal product
(although
premium MCHC supplements use free-range, pasture-fed livestock from
countries
like New Zealand or Australia as sources for the raw materials).
For vegetarians, the best
calcium source is calcium citrate-malate.
Calcium citrate-malate is
not the same thing as calcium citrate, or as a simple admixture of
calcium
citrate and calcium malate. Calcium citrate-malate is prepared in such
a way that a significant number of its calcium atoms are bound to both
citrate and malate molecules at once. This unique form makes calcium
citrate-malate
six to nine times more easily dissolved in the stomach than plain
calcium
citrate.
This superior solubility
may be at least part of the reason for the fact that calcium
citrate-malate
is considerably better-absorbed than calcium citrate. And calcium
citrate-malate
has been used successfully in many controlled trials to support bone
mass
and/or to lower fracture risk. Some of these trials have involved a
direct
face-off between calcium citrate-malate and other forms of calcium.
Such
trials demonstrate that, as might be expected from its greater
bioavailability,
calcium citrate-malate gives better protection to the bones than other
vegetarian calcium sources – although its effects are still not
as impressive
as those of MCHC.
• Don’t fall
for the “Coral
Calcium” Hype. Some companies are making wild claims about the
efficacy
of calcium taken from coral reefs, not just for osteoporosis but for
almost
every ailment under the sun. These claims are simply bogus. There is
nothing
magical about “coral calcium:” it is actually almost
entirely calcium carbonate,
with a sprinkling of some trace minerals. Not one clinical trial has
ever
been performed to show that “coral calcium” is better
absorbed or better
utilized than other conventional calcium sources. Instead,
astoundingly,
the claims of high bioavailability for “coral calcium” are
not based on
controlled studies in humans, but on the stuff’s ability to
dissolve in
water; and as has been shown, such a silly test bears little
relationship
to the ability of a living body to absorb calcium.
Bottom line: take your calcium in the
form of MCHC if you are comfortable with animal products; choose
calcium
citrate-malate if you’re not.
• Rock Around the
Clock.
Several recent studies have suggested that when you take your calcium
can
make a big difference in terms of both the amount of calcium
you’ll absorb,
and the effects of that calcium on your bones. For starters, take your
calcium with food, as doing so will increase absorption. It’s
also important
to spread your calcium supplements over the course of the day, which
increases
your total absorption of calcium and keeps parathyroid hormone (PTH)
under
control throughout the day. To get the best possible results, take the
largest single dose of calcium later in the day, at dinner or with a
late-night
snack.
• Take Enough Vitamin
D. Aside from improving calcium absorption, vitamin D is needed
for proper muscle function, which may play a role in protecting against
fractures by reducing falls. But you simply can’t rely on the sun
to meet
your requirements, especially in Northern climates. Even in sunny
Spain,
researchers have found that 80% of children have inadequate vitamin D
levels
in March and October. In fact, in one remarkable recent study,
researchers
at Creighton University were able to document that even North Americans
who spend nearly all day in the sun during the summer (such as
landscapers
and agricultural workers) were still at a 58% risk of being too low in
vitamin D to support optimal calcium metabolism by the end of the
winter!
From what we now know, the
old RDA of 400 IU will not protect you from vitamin D insuffciency
except
in the sunniest of climates. Studies show that a 400 IU vitamin D
supplement
is just not enough to keep serum levels of the active vitamin above the
cutoff for insufficiency, and the use of 400 IU supplements have not
been
shown to reduce fracture rates. Even 600 IU has little effect on BMD.
Instead,
controlled studies show that vitamin D, together with calcium, helps to
reduce the risk of fracture at a dose of at least 800 IU per day and
recent
trials suggest much higher dosages are needed to maintain optimal blood
levels.
Take a magnesium you can
absorb. Magnesium citrate is
absorbed at 29.64%,(click here
to
see information about highly absorbable Transdermal Magnesium)
but much better absorption is available from other forms –
especially fully-reacted
magnesium aspartate, with a remarkable 41.7% bioavailability.
• Small Doses
… Big Benefits!
Just a small amount of some key nutrients can play a big role in the
health
of your bones. Among the most well-known are manganese, zinc, and
copper,
as well as other, even more commonly-neglected nutrients such as silicon,
boron, and vitamin C. Methylating nutrients such as vitamin B12 and
folic
acid may also be important to bone health, perhaps because of the toxic
effects of homocysteine on the protein fibers in bone.
More recently,
Menatetrenone
and Strontium have emerged as bone-building superstars. Menatetrenone
is
a specific form of vitamin K2, not to be confused with the common
phylloquinone
(vitamin K1) or even the bacterial menaquinones (which are also forms
of
vitamin K2). Multiple clinical trials show that megadose Menatetrenone
supplements reduce fracture rates in osteoporotic women as well as
Fosamax®-type
drugs, without having much influence on bone mineral density;
apparently,
they work their magic by improving the quality of the bone itself.
Strontium,
the neglected bone health mineral, appears to be the first truly
bone-building
nutrient, as opposed to supplements like calcium and vitamin D (or even
estrogen therapy) or bisphosphonates (such as Fosamax® ), which
work
primarily by preventing the breakdown of old bone.
Younger, healthier people
looking to support their basic bone health should consider taking these
nutrients at kind of doses equivalent to what’s found in the best
diets:
5 milligrams of Strontium, and a few hundred micrograms of
Menatetrenone.
Clinical trials to treat women with full-blown osteoporosis use much
higher
doses: 45 milligrams of Menatetrenone, and 600 to 700 milligrams of
Strontium.
• The Phosphorus
Paradox.
It’s widely believed that Western diets are too rich in this
mineral, and
that excess phosphorus is bad for bone health. But phosphorus is an
essential
nutrient, which makes up more than half of the mineral content of bone
and which is needed for osteoblast function. Nearly a third of older
Americans
don’t get the new RDA of this essential mineral.
• The Bone Health
Lifestyle.
Beyond targeting your intake of specific nutrients, there are a lot of
important choices you can make which can spell the difference between
building
strong bones and slowly sinking into osteoporosis. Fortunately, each of
these choices also has positive impacts on other aspects of your
health,
so that they are part of an overall healthy lifestyle and not a whole
new
checklist of health practices. Eat an “alkaline-ash” diet,
rich in fruits
and vegetables. But get enough protein, which is necessary for building
the collagen network in which bone mineral is embedded: the optimal
intake
of protein to support a healthy skeletal system appears to be in the
range
of 1.0 to 1.5 grams per kilogram of body mass, or 0.45 to 0.68 grams of
protein for each pound that you weigh. Keep active focusing on
weigh-bearing
exercise. Maintain a healthy weight, quit smoking, and if you drink, do
so in moderation.
The choices are yours to
make. They’re simple to understand and easy to follow. And the
greatest
prize – your health – is yours to claim.
The information and
product
descriptions appearing on this website are for information purposes
only,
and are not intended to provide medical advice to individuals. Consult
with your physician if you have any health concerns, and before
initiating
any new diet, exercise, supplement, or other lifestyle changes. Source
of information above is:
Copyright © 2005,
Advanced
Orthomolecular Research
For information on how to order Strontium,
Ortho Bone and other products for bone health,
To see all our products
and order Please click here to go to our
online
Catalog
For additional information on how to
prevent osteoporosis, check this
article written by Dr John Lee and Virginia Hopkins. Virginia has a
wealth of information on her site.
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